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Importantly, for both STVs and PTVs, encountering the other type of vesicle increases their propensity to pause.

Second, individual PTVs and STVs share pause sites within the axon. First, a significant proportion of STVs and PTVs are transported together before forming a stable terminal. Here, using time-lapse confocal imaging of the dynamics of PTVs and STVs in the same axon, we show that vesicle trafficking is coordinated through at least two mechanisms. Although both PTVs and STVs are recruited to the same site in the axon, often within minutes of axo-dendritic contact, it is not known whether or how PTV and STV trafficking is coordinated before synapse formation. Prior to synapse formation, active zone proteins and synaptic vesicle proteins are transported along axons in distinct organelles referred to as piccolo-bassoon transport vesicles (PTVs) and synaptic vesicle protein transport vesicles (STVs), respectively. For more information, click here.The proteins required for synaptic transmission are rapidly assembled at nascent synapses, but the mechanisms through which these proteins are delivered to developing presynaptic terminals are not understood. I understand that these countries may not have the same data protection laws as the country from which I provide my personal information.

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